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Rabbit Oral Papillomatosis: Ultrastructure of Experimental Infection¹

Departments of Pathology and Infectious Disease, Abbott Laboratories, North Chicago, Illinois

Oral papillomatosis of the rabbit was produced by experimental inoculation with tissue homogenates, its course of development being studied by gross observation and electron microscopy. Prior to the formation of a definite papilloma, the inoculation site was edematous and no virus could be demonstrated. Gross evidence of a well-defined tumor coincided with the finding of the virus at 14 days postinoculation. After 28 days, signs of regression of the tumor were noted. At the termination of the experiment, which was 100 days postinoculation, the tumor was small and less well defined; although regression was pronounced, the virus was still demonstrable. The well-developed tumors of experimentally infected rabbits appeared the same, and the ultrastructure was similar in all respects to the naturally occurring rabbit oral papillomatosis.

¹ This work was supported in part by the NIH under Contract PH 43-63-557 and the Cancer Chemotherapy National Service Center, National Cancer Institute.

Received 6/ 1/65.

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