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An Electron Microscope Study of Squamous Cell Carcinoma in Merino Sheep Associated with Keratin-filled Cysts of the Skin

Department of Veterinary Pathology and Bacteriology and the Electron Microscope Unit, University of Sydney, Sydney, Australia

The fine structure of a naturally occurring cystic condition of the skin in Merino sheep and associated squamous cell carcinoma was studied and compared with the fine structure of the normal interfollicular epidermis of the sheep. A number of obvious differences were observed—namely, large intercellular spaces, microvillus formation, gaps in the basement membrane, fewer desmosomes, and in the tumor cells only, 2 large nucleoli with a prominent nucleolonema.

Received 4/26/65.