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Mithramycin Inhibition of Ribonucleic Acid Synthesis¹

Departments of Medicine and Biochemistry, University of Minnesota Medical School, Minneapolis, Minnesota

Mithramycin, an antibiotic derived from an organism belonging to the genus Streptomyces, was studied in mouse ascites tumor and mouse liver by measuring its effect on the incorporation of phosphate-³²P into RNA and DNA in vitro and in vivo. A marked inhibition of incorporation into the RNA of the tumor and liver was observed with no measurable effect upon incorporation of isotope into the DNA of the ascites tumor. The effect was similar to that of actinomycin D in time of onset, but mithramycin was observed to be only about 0.1 times as potent as actinomycin D in this respect.

¹ This research was supported in part by Public Health Research Grants No. CA-01747-13 and CA-03143-08 from the National Cancer Institute and Public Health Service Training Grant No. T4-CA-5158 from the National Cancer Institute.

Received 5/ 3/65.

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