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Spontaneous Tumorigenesis in Hypophysectomized Syrian (Golden) Hamsters¹

Sloan-Kettering Institute for Cancer Research, New York, New York, and Children's Cancer Research Foundation, Boston, Massachusetts

Hormonal influences on spontaneous tumorigenesis have been studied in 90 hypophysectomized male Syrian (golden) hamsters which survived a mean of 12.3 months after operation. The incidence and types of spontaneous tumors were comparable in hypophysectomized and sham-operated animals, with the exception of tumors of endocrine glands and accessory reproductive organs. Of particular interest was the occurrence of melanomas, intestinal polyps and adenocarcinomas, and lymphosarcoma in hamsters following hypophysectomy. There was no apparent effect on the propensity of various tumors to metastasize.

The restriction of spontaneous tumors to certain sites in hypophysectomized hamsters may correlate with the extent to which pituitary hormones contribute to normal tissue integrity.

¹ This study was supported by NIH Grant CA-03817.

Received 2/ 7/66.