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Induced Mammary Carcinoma in the Female Rat as a Drug Evaluation System¹

Kettering-Meyer Laboratory (Affiliated with Sloan-Kettering Institute), Southern Research Institute, Birmingham, Alabama

Following the observation of Huggins et al., preliminary experiments have been carried out with the view to developing parameters necessary in the adaption of the 7,12-dimethylbenzanthracene (DMBA)-induced mammary adenocarcinoma in the female rat for the routine evaluation of potential anticancer agents being considered for trial against certain cancers of the breast in women or in a search for new agents possibly worthy of such consideration.

The hormone dependence of the primary DMBA-induced mammary carcinoma rather closely parallels its human counterpart. This has been borne out by the response to hypophysectomy, ovariectomy, and treatment with testosterone propionate and certain other steroids. The effect of host body weight loss on tumor growth is definable to a limited extent; tumor induction utilizes a procedure (a single intragastric dose of DMBA) of relative ease and one which provides a large tumor yield; and tumor growth rates, regardless of site or size, are not too dissimilar.

It would appear from the data presented by Huggins et al. and the confirmatory results presented herein that this tumor system does indeed offer a usable and promising tool for evaluating the potential of trial agents.

¹ This work was supported by Contract No. SA-43-ph-4358 with the Cancer Chemotherapy National Service Center, National Cancer Institute, NIH.

Received 2/21/66.

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