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Nonspecific Esterases in Normal and Neoplastic Tissues of the Syrian Hamster: A Zymogram Study¹

Department of Anatomy, Stanford University School of Medicine, Stanford, California

The normal tissues and 18 tumor types of the Syrian hamster were studied electrophoretically and stained selectively for esterases, and the 2 groups were compared. Esterase banding patterns of normal tissues appeared to be distinct from one another to a degree which roughly paralleled structural and functional differences. With very few exceptions, tumor patterns did not resemble those of parent tissues, but did exhibit a marked tendency to assume a common pattern.

¹ This work was supported in part by the Institutional Research Grant IN-32-G from the American Cancer Society and by Grants CA-04516-07 and AM-08111-01 from the NIH.

Received 3/ 1/66.