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Heterotransplantation of Human Leukemic Cells and Cell Cultures in the Lethally X-irradiated Syrian Hamster¹

The Children's Cancer Research Foundation, and Department of Pathology, Harvard Medical School, at the Children's Hospital, Boston, Massachusetts

Lymphoblasts obtained directly from the peripheral blood buffy coat of a child with acute lymphoblastic leukemia partially or completely repopulated the depleted bone marrow spaces of 2 hamsters i.v. infused shortly after whole body irradiation in the supralethal dose range. A more extensive series of experiments with lymphoblasts (CCRF-CEM) isolated directly in continuous suspension cultures from the same patient's blood buffy coat, gave similar results. These results are discussed in terms of the potential utility of this kind of experiment, based on the bone marrow protection model, for (a) the heterotransplantation of human leukemic cells; (b) investigation of the biology of human leukemic cells; and (c) the "monitoring" of cell cultures of hemic or lymphoid origin.

¹ These studies were supported in part by research grant C-6516 from the National Cancer Institute, USPHS.

² Holds Research Career Award 1-K6-CA-22, 150 from the National Cancer Institute.

Received 3/15/66.