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Mammary, Sebaceous, and Cutaneous Neoplasms and Leukemia in Male Wistar Rats Receiving Repeated Gastric Instillations of 3-Methylcholanthrene¹

Fels Research Institute, Temple University School of Medicine, Philadelphia, Pennsylvania

Wistar rats were given daily intragastric instillations of 5 mg of 3-methylcholanthrene in olive oil for 9 weeks, for a total of 270 mg. Among 81 intact males, surviving for 8–33 weeks, there occurred 11 mammary carcinomas in 10 rats, 2 fibroadenomas, 4 sebaceous gland carcinomas and 11 sebaceous gland adenomas, 5 cutaneous basal cell carcinomas, 2 epidermoid carcinomas and 6 benign epitheliomas, and 5 leukemias. Among 122 intact females, 106 developed 286 mammary carcinomas, 2 fibroadenomas, 1 sebaceous gland carcinoma and 1 benign epithelioma, and 10 leukemias. Cutaneous carcinogenesis appears almost as sexspecific for males as mammary carcinogenesis is for females. A Cesarian-derived foster-nursed line of rats had the same carcinogenic response as the conventional Wistar line.

¹ This work was supported in part by Grant CA-07771 from the National Cancer Institute, NIH, USPHS.

Received 3/25/66.