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Neoplasms Evoked in Male Sprague-Dawley Rat by Pulse Doses of 7, 12-Dimethylbenz(a)anthracene¹

The Ben May Laboratory for Cancer Research, University of Chicago, Chicago, Illinois

In male rats of the Sprague-Dawley strain a single pulse dose of 7,12-dimethylbenz(a)anthracene elicited a few mammary and sebaceous gland carcinomas but leukemia was not observed. Multiple pulse doses enhanced the yields of these tumors and, in addition, evoked leukemia in rather high incidence.

The induced mammary cancers of male rats did not regress after orchiectomy and hypophysectomy; hence they were hormone-independent.

¹ This work was supported by grants from the Jane Coffin Childs Memorial Fund for Medical Research and the American Cancer Society.

Received 4/21/66. Accepted 5/24/66.