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Effects of Hydroxyurea and Related Compounds on the Blood and Marrow of Experimental Animals

Squibb Institute for Medical Research, New Brunswick, New Jersey

Hydroxyurea prevented the leukocytosis that occurs in mice inoculated with L1210 leukemia. This activity probably accounted for the increase in survival time which was found in these animals when they were treated with hydroxyurea.

Hydroxyurea also reduced all blood cellular elements in the immature male rat in direct relationship to the dose employed. The highest daily dose employed in this study (125 mg/rat) also caused a reduction in body weight gain, food consumption, and endocrine organ weights.

Compounds related to hydroxyurea were also effective in reducing the number of RBC and WBC in the rat. Several of these decreased the WBC while not affecting the other end points examined.

Received 11/15/65. Accepted 6/ 1/66.