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Effect of Hydroxyurea on Growth of a Transplantable Mouse Mammary Adenocarcinoma

Squibb Institute for Medical Research, New Brunswick, New Jersey

Growth of mammary adenocarcinoma H2712 is inhibited by hydroxyurea. This compound was effective by daily, intermittent, or single s.c. injection. It was also effective when administered directly into the tumor.

Hydroxyurea is most efficacious when administered prior to the onset of rapid growth.

Simultaneous administration of hormones with antitumor activity in this system did not augment the effects of hydroxyurea.

Received 11/15/65. Accepted 5/24/66.