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Effects of 17-Thioestradiol, 2 Estradiol Analogs, and 2 Androgens on 7, 12-Dimethylbenz[a]anthracene-induced Rat Mammary Tumors¹

Division of Experimental Chemotherapy, Sloan-Kettering Institute for Cancer Research, New York, New York

A thiol analog of estradiol, 17-thioestradiol, was tested for antitumor activity in the 7, 12-dimenthylbenz(a)anthracene-induced mammary tumor-rat experimental chemotherapy system. Its effects were compared with those produced by 17-estradiol, 17ß-estradiol, testosterone propionate (TP), and 2-methyldihydrotestosterone propionate (2-MDTP). Of the estradiols, the largest proportion of complete remissions (CR) of all tumors in each rat was produced by 17ß-estradiol (67%) followed by 17-thioestradiol (50%) and 17 estradiol (37%). Among the androgens, 2-MDTP yielded 70% and TP yielded 44% CR. The median duration of tumor-free status after treatment was 12, 12, 18, 33, and 8.5 weeks, respectively, for 17ß-estradiol, 17-thioestradiol, 17-estradiol, 2-MDTP, and TP.

¹ Supported by Contracts SA-ph-2445 and PH 43-65-619 from the Cancer Chemotherapy National Service Center, National Cancer Institute, NIH, USPHS and by NCI Grant CA 08748.

Received 1/ 7/66. Accepted 5/25/66.