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Studies on Connective Tissue Tumors in the Hamster Produced by Bovine Papilloma Virus

National Animal Disease Laboratory, Ames, Iowa

Bovine papilloma virus was injected s.c. and intracerebrally in newborn and weanling hamsters. Connective tissue tumors (fibromas, chondromas, and meningiomas) were produced in the subcutaneous regions of the back, pinna of the ear, and the meninges. The tumors did not contain evidence of viral infection when examined by histologic, immunofluorescent, and electron microscopic means. The tumors grew rapidly but remained localized and encapsulated. Large tumors consisted of masses of collagen fibers with a zone of active fibroblasts on the periphery.

Received 4/ 4/66. Accepted 6/ 8/66.