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Diaplacental Effect of the Carcinogen Diethylnitrosamine in the Golden Hamster

German Cancer Research Center, Heidelberg, and the Institute for Experimental Pathology, Heidelberg, Germany

The action of diethylnitrosamine (DENA) was tested on pregnant golden hamsters. After administration of doses totaling 0.002–0.014 gm (daily dose, 0.002 gm) during pregnancy, the young were examined at various intervals after birth. At 25 weeks after birth, 42% of the animals exhibited tracheal papilloma, some multiple. Of the treated mothers, 73% developed tracheal papilloma, again partly multiple, 25 weeks after the 1st administration of the drug. Within the same interval, 88% of the young and 71% of treated mothers showed alterations of the liver with varying changes in parenchymal structure.

When newborn hamsters from treated and untreated mothers were exchanged, only the young of treated mothers developed papilloma. The passage of DENA through the placenta after intracardial injection of the drug was proved by thin-layer chromatography. The resulting injury to the liver (cirrhosis) is also revealed by reduced incorporation of ³²P.

Received 12/ 2/65. Accepted 6/ 8/66.