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Lack of Secretion of Serum Protein by Transplanted Rat Hepatomas¹

The McArdle Laboratory for Cancer Research, University of Wisconsin Medical Center, Madison, Wisconsin, and Laboratory of Biochemistry, National Cancer Institute, NIH, USPHS, Bethesda, Maryland

The participation of the Reuber hepatoma H35 TC and of the Morris hepatomas 5123 TC and 9121 in the production of serum protein was investigated by studying the metabolism of radioactive (¹⁴C) amino acids in totally eviscerated tumor-bearing rats. A part of the injected amino acids was oxidized to ¹⁴CO₂, another part was incorporated into tumor protein, but no secretion of labeled protein into stream could be detected.

¹ These studies were supported by grants from the American Cancer Society (E6), the USPHS (CRTY-5002), and the Alexander and Margaret Stewart Trust Fund.

² Supported by a NATO Postdoctoral Research Fellowship, Deutscher Akademischer Austauschdienst, Bad Godesberg, Germany. Present Address: Department of Biochemistry and Medicine, College of Physicians and Surgeons of Columbia University, New York, N. Y.

³ We are very much obliged to Mrs. Carolyn Muckerman for her skillful technical assistance.

Received 1/27/66. Accepted 6/ 8/66.