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Rat Skin Carcinogenesis by Topical Applications of Some Azo Dyes¹

University of Birmingham, Cancer Research Laboratories, Department of Pathology, The Medical School, Birmingham, England

Groups of 6 male rats were painted twice weekly with 1 ml of a 0.2% solution of an azo dye in acetone. The dyes used were aminoazobenzene, 4-monomethylaminoazobenzene, their 3-methoxy analogs, and 4-dimethylaminoazobenzene. In each case, all rats developed multiple skin tumors of histologic types similar to those found in rats treated with other chemical classes of carcinogen. 3-Methoxy-4-monomethylaminoazobenzene was the most potent carcinogen, followed by 4-monomethylaminoazobenzene, 3-methoxyaminoazobenzene, and 4-dimethylaminoazobenzene, and finally aminoazobenzene.

3-Methoxy-4-dimethylaminoazobenzene, which is also a potent carcinogen for rat skin, was found to be totally ineffectual when painted on the skins of 280 mice.

¹ This work was supported by the Birmingham Branch of the British Empire Cancer Campaign for Research.

² Present address: Glaxo Laboratories, Ltd., North Lonsdale Road, Ulverston, Lancashire, England.

Received 4/29/66. Accepted 6/17/66.