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S-Adenosylmethionine-synthesizing Activity of Normal and Neoplastic Mouse Tissues¹

The Jackson Laboratory, Bar Harbor, Maine

An enzyme which synthesizes S-adenosylmethionine in mouse liver has been examined and found to possess the same characteristics as that described by others for pig and rabbit liver. Although liver has large quantities of the enzyme activity, a mouse hepatoma had no measurable activity. It was hypothesized that trace amounts of the enzyme in hepatoma cells might be sufficient for sRNA methylation. Estrogen was found to depress the activity of liver S-adenosyltransferase in castrate female mice.

¹ This investigation was supported in part by an allocation from a Public Health Service General Research Support Grant No. SO 1 FR-05545-01, and an American Cancer Society Grant IN19F to The Jackson Laboratory, Bar Harbor, Maine.

Received 4/ 6/66. Accepted 6/17/66.