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Preclinical Studies with Vinglycinate, One of a Series of Chemically Derived Analogs of Vinblastine

The Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana

The antitumor activity of a series of 4-acyl and -aminoacetyl analogs of vinblastine is described. Marked differences in activity and toxicity were observed. One of the -aminoacetyl analogs, vinglycinate, produced therapeutic effects in experimental tumors similar to those observed with vincristine, including 100% "cure" of the P-1534 leukemia, but with a greatly reduced toxicity.

Received 2/ 7/66. Accepted 6/17/66.