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Cortisone and Hamster Buccal Pouch Carcinogenesis

Department of Oral Pathology, Tufts University School of Dental Medicine, Boston, Massachusetts

Ninety male Syrian hamsters, 3 months of age, were divided into 6 equal experimental groups of 15 animals. Two groups served as controls for 8- and 16-week experimental periods. In the remaining 4 groups, the right buccal pouch was painted 3 times weekly with 9,10-dimethyl-1,2-benzanthracene (DMBA) and sacrificed at 8 and 16 weeks. One 8-week and one 16-week experimental group were also injected 3 times weekly with 2.0 mg of cortisone acetate. It was found that in those animals receiving cortisone as well as DMBA applications, the development of initial dysplasia and of buccal pouch carcinomas was hastened. Although the tumors induced in the cortisone-DMBA animals were histologically not more anaplastic than those in the DMBA animals, invasion of underlying connective tissue and muscle was more extensive and the tumors were considerably larger in size. Metastasis to regional lymph nodes was not observed in any of the groups.

Received 5/26/66. Accepted 6/27/66.