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Immunologic Tolerance to Human Cancer Transplants in Rats¹

Sloan-Kettering Institute for Cancer Research, New York, New York

Visceral implants of human cancer cells were produced in normal rats by i.v. injection of suspensions of tissue-cultured cell lines before age 24 hr. Such rats, even at 3 weeks of age, would frequently accept s.c. or i.p. transplants of the same or other human cancer cell lines. Littermates which were not given the i.v. inoculum did not accept s.c. or i.p. transplants, even when newborn. Evidence is presented which indicates that this acceptance of a heterograft is due to immunologic tolerance specific for human cells and lasts only so long as human cell antigens persist in the recipient.

¹ Supported by a grant from the National Cancer Institute, USPHS Grant Nos. CY 3215 and CA 08748.

Received 8/19/65. Accepted 6/28/66.