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Normal Mouse Erythropoiesis

I. The Role of the Spleen in Mouse Erythropoiesis¹

Department of Medicine, Section of Hematology, Hahnemann Medical College and Hospital, Philadelphia, Pennsylvania

Erythropoiesis in normal Swiss Webster female mice was studied by routine hematologic parameters, ferrokinetics (⁵⁹Fe), the uptake into and release of ⁵⁹Fe from the spleen, and RBC survival (⁵¹Cr). The mean radioiron clearance (⁵⁹Fe T)² is 61.7 min; plasma iron turnover is 2.4 mg/24 hr/100 ml of whole blood; and the reappearance of ⁵⁹Fe is 62.4% and 82.0% at 24 and 48 hr, respectively. The RBC survival (⁵¹Cr T), with the use of wholebody counting, is 19.0 days. With the use of whole blood technics, the ⁵¹Cr T is 12–15 days. The uptake into and release of ⁵⁹Fe from the spleen parallels the ⁵⁹Fe T and ⁵⁹Fe reappearance in the RBC. The data in this study indicate that, from the standpoint of erythropoiesis, the mouse spleen is analogous to bone marrow.

¹ This investigation was supported by Grant E 305 from the American Cancer Society, and Grant CA 06832 from the USPHS, National Cancer Institute.

² T, half life.

Received 5/24/65.