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Genetic and Possible Biochemical Mechanisms in Viral Carcinogenesis¹

McArdle Laboratory, University of Wisconsin, Madison, Wisconsin

Rous sarcoma virus infects and rapidly converts normal cells into malignant ones. The infection involves the formation of new DNA genes in the cell, although the virus particle of RSV² contains RNA. These new genes may be inactive, in which case the infected cells appear normal, or the new genes may be active, in which case the properties of the infected cell change. These changes in the infected cell are specific and include increases in the production of acid mucopolysaccharides, in glycolysis, and in the ability to grow in some circumstances.

The effects of other tumor viruses and carcinogens are briefly compared with the effects of RSV.

¹ Presented at a symposium on "Biochemical Alterations Induced by Virus Infection" given at the 56th annual meeting of the American Association for Cancer Research at Philadelphia on April 8, 1965. Supported by USPHS Grant CA-07175 and Research Career Development Award 1-K3-CA-8182 from the National Cancer Institute.

² The abbreviations used are: RSV, Rous sarcoma virus; FUDR, fluorodeoxuridine; AMPS, acid mucopolysaccharides; and FFU, focus forming units.

Received 7/ 7/65.