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The Effect of Corticosteroids and Altered Adrenal Function on Liver Regeneration following Chemical Necrosis and Partial Hepatectomy

Endocrine Unit, Department of Pathology, University of Liverpool, England

The inhibitory effect of cortisol on the mitotic rate of the proliferating liver of the mouse has been confirmed. When the initial liver damage had been caused by carbon tetrachloride, cortisol produced an inhibition with a linear log-dose response. Cortisol, corticosterone, and ACTH¹ all produced inhibition of mitosis after partial hepatectomy. Various nonspecific procedures, such as starvation or slightly painful injections, also lowered the mitosis rate; this effect was abolished by adrenalectomy.

¹ The abbreviations used are: ACTH, adrenocorticotropic hormone; DOCA, deoxycorticosterone acetate.

Received 2/15/65. Revised 7/23/65.