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Plasma Enzymes in Tumor-bearing Rats

Biomedical Division, The Samuel Roberts Noble Foundation, Inc., Ardmore, Oklahoma

The plasma enzymes, lactic dehydrogenase, glutamic oxalacetic transaminase, and malic dehydrogenase, increased progressively in tumor-bearing rats. The amount of increase varied markedly with the type of tumor and the site of implantation. A lactic dehydrogenase agent could not be demonstrated in any of these animals. Isozyme patterns indicated the tumor was a significant contributor to the increased lactic dehydrogenase in the plasma of these rats. The plasma lactic dehydrogenase was increased less in animals that bore a tumor contaminated with bacteria. The clearance rate of lactic dehydrogenase was slower than normal in tumor-bearing rats, and it decreased progressively with tumor growth.

Received 5/ 3/65. Revised 8/ 9/65.