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-Aminolevulinic Acid Dehydrase Activity in Friend Virus-Infected Mice¹

Endocrine Section, Department of Chemistry, and Department of Pathology and Microbiology, Colorado State University, Fort Collins, Colorado

The -aminolevulinic acid dehydrase (DALAD)² activity sharply increased in the spleen and liver of mice 1 week after inoculation with Friend virus (FV). FV causes leukemia and polycythemia in mice. The increase in DALAD activity corresponded to an increased ⁵⁹Fe uptake in the spleen and liver, which indicates that DALAD activity is a useful parameter of erythropoietic activity. The data suggest that DALAD may be the key enzyme in hemoglobin biosynthesis.

¹ This research was supported in part by American Cancer Society Institutional Research Grant No. IN-83A.

² The abbreviations used are: DALAD, -aminolevulinic acid dehydrase; FV, Friend virus; PBG, porphobilinogen; FV-R, Friend virus from the Roswell Park Memorial Institute; and EPF, rabbit plasma erythropoietic factor.

Received 6/24/65.