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Steroid-induced Increase in Survival of Tumor-bearing Rats¹

Worcester Foundation for Experimental Biology, Shrewsbury, Massachusetts

2-Methyl-17ß-hydroxy-5-androstan-3-one significantly increased the survival time of rats bearing mammary fibro adenomas. The extent of survival was related to the hormone responsiveness of the tumor.

¹ Supported by USPHS Contract SA-43-ph-4354 from the Cancer Chemotherapy National Service Center, National Cancer Institute, NIH, and by Grant No. T-285 from the American Cancer Society.

² Present address: Institute of Hormone Biology, Syntex Research Center, Palo Alto, California.

Received 1/29/65. Revised 7/29/65.