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Response of Wistar Rats with Breast Cancer Induced by 3-Methylcholanthrene to Thirty-One Compounds¹

( Fels Research Institute, Temple University School of Medicine, Philadelphia, Pennsylvania)

Twenty-three nonhormonal and 8 hormonal agents were tested for antineoplastic activity against mammary carcinoma induced by gastric instillations of 3-methylcholanthrene (NSC-21970) in female Wistar rats. Three nonhormonal agents were active: NSC-185 (actidione), NSC-26980 (mitomycin C), NSC-37095 (AB-100); 4 hormonal agents were active: NSC-741 (hydrocortisone acetate), NSC-3070 (diethylstilbestrol), NSC-9566 (17ß-estradiol, 3-benzoate), and NSC-12198 (4,5-dihydro-2-methyltestosterone propionate). The results were compared with results, reported by other investigators, of testing the agents against Adenocarcinoma 755, a transplanted mouse tumor.

¹ Supported by contract SA-43-ph-4344 from the Cancer Chemotherapy National Service Center, National Cancer Institute, National Institutes of Health, Public Health Service.