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On the Mechanism of Urethan Leukemogenesis in Newborn C57BL Mice

I. Influence of Injections of Syngeneic Bone Marrow Cell Suspensions¹

Department of Experimental Biology, The Weizmann Institute of Science, Rehovoth, Israel

Injections (i.v.) of syngeneic bone marrow cell suspension failed to inhibit urethan leukemogenesis in newborn C57BL/6 mice, in contrast to the known inhibition of radiation leukemogenesis by bone marrow in adult mice of the same strain. Other differences in the mode of action between whole-body X-irradiation and urethan are discussed in the light of the present results.

¹ This investigation was supported by Research Grant CA-05455 of the National Cancer Institute, USPHS.