This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Dmochowski, L. Articles by Young, L. Search for Related Content PubMed PubMed Citation Articles by Dmochowski, L. Articles by Young, L.

Studies on the Biologic Relationship of Some Murine Leukemia Viruses¹

Department of Virology, The University of Texas M. D. Anderson Hospital and Tumor Institute, and Department of Microbiology, Baylor University College of Medicine, Texas Medical Center, Houston, Texas

Moloney and Passage A virus induced lymphatic leukemia in BALB/c/Dm/TEX and in AKR/Dm/TEX strain mice. Friend virus and Rauscher virus induced a high incidence of erythroid leukemia in mice of the same strains. Uninoculated BALB/c/Dm/TEX mice had a 0.1% incidence of spontaneous leukemia, and AKR/Dm/TEX mice an 83% incidence.

Glomerulonephritis was observed in AKR mice with advanced leukemia (but not in BALB/c mice) following inoculation of Friend or Rauscher virus. Differences in leukemia-inducing activity in BALB/c mice were noted between Passage A and Moloney virus and between Friend and Rauscher virus in BALB/c and AKR mice. Moloney, Friend, and Rauscher virus, after 1 passage in AKR mice, showed apparent decrease of leukemia-inducing activity in BALB/c mice.

Inoculation of BALB/c mice with Moloney virus, followed 24 hr later by Passage A virus, resulted in a lower incidence and a shorter latent period of lymphatic leukemia compared with leukemia induced by Moloney virus alone. BALB/c mice inoculated with Moloney virus, and 24 hr later with Rauscher virus, showed a lower incidence of Rauscher leukemia and a shorter latent period compared with mice inoculated with Rauscher virus alone. While only 1 animal developed Rauscher leukemia, 50% of the mice developed lymphatic leukemia.

Inoculation of BALB/c mice with Moloney virus followed by Friend virus induced Friend leukemia except in 1 animal which developed lymphatic leukemia. The incidence of Friend leukemia was lower than that induced with Friend virus alone. Inoculation of BALB/c mice with Passage A virus, followed by Friend virus, induced a lower incidence of Friend leukemia than with Friend virus alone. BALB/c mice inoculated with Passage A, followed by Rauscher virus, showed a similar incidence of Rauscher leukemia to that of mice inoculated with Rauscher virus alone.

The latent period of erythroid leukemia in BALB/c mice inoculated with Friend virus followed by Rauscher virus was shorter than that of similar leukemia induced by either virus.

¹ Supported in part by USPHS Grant CA-04140-06 and by Grant E-94-E from the American Cancer Society, Inc.

² Formerly Fellow in Virology of the Department of Pathology, Fellow of the Leukemia Society, Inc.

³ Fellow of the China Medical Board of New York, Inc.