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Ovarian Tumorigenesis in Irradiated Parabiotic Rats¹

Cancer Research Institute of the New England Deaconess Hospital, Boston, Massachusetts, and the Department of Pathology, Francis Delafield Hospital, New York, New York

Supralethal total-body X-irradiation of one parabiont rat with its partner shielded was followed by a growth of unilateral or bilateral ovarian Sertoli-cell tumors in about 20% of exposed animals. Granulosa-theca cell ovarian tumors and gynandroblastomas occurred less often. The tumorigenic process began with irradiation, regardless of age, and Sertoli-cell tumors developed earlier and more frequently than in normal single controls. Parabiosis without irradiation did not result in ovarian tumorigenesis.

¹ This work was supported by U. S. Atomic Energy Commission Contract AT(30-1)-901 with the New England Deaconess Hospital (NY0-901-35).