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Factors Controlling Metastasis of Experimental Breast Cancer¹

Roswell Park Memorial Institute, New York State Department of Health, Buffalo, New York

Rats bearing a large mammary adenocarcinoma, induced by methylcholanthrene (MCA), whether it is an autochthonous or a transplanted isologous tumor, often had an enlarged spleen without metastatic involvement of any organs. Such spleens contained many tumor cells in the venous sinuses. When blood and spleen-mince obtained from the tumor host were inoculated separately into the peritoneal cavity of young adult isologous rats, they produced numerous tumor nodules in the abdomen in all rats. It was concluded, therefore, that the rationale for not finding metastasis in the rat bearing an MCA-induced mammary tumor is in the host immune state evoked by the strong specific antigenicity of the tumor. The possible mechanism controlling metastasis of breast cancer is also discussed.

¹ Supported in part by a grant from the Hartford Foundation and Contract SA-43-ph-2398 with the Cancer Chemotherapy National Service Center, National Cancer Institute, NIH.