This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Messier, B. Search for Related Content PubMed PubMed Citation Articles by Messier, B.

Action of Thyroid Hormones and Diethylstilbestrol on the Gonadotropic Activity of a Mouse Thyrotropic Tumor¹

Institut du Cancer de Montréal, Laboratoires de Recherche, Hôpital Notre-Dame et Université de Montréal, Montréal, Canada

Mice bearing a grafted thyrotropic tumor manifested secondary gonadotropic effects. Ovaries and uterus increased in weight, whereas seminal vesicles were significantly atrophied. These changes were corrected when the growth of the tumor was inhibited with l-thyroxine (T₄) or l-triiodothyronine (T₃). Attempts to inhibit only the gonadotropic activity with diethylstilbestrol (DES) proved unsuccessful. On the contrary, DES enhanced tumor growth in females with concomitant increase in mean ovarian weight, whereas in males, tumor growth was decreased by DES.

¹ This investigation was supported by a grant from the National Cancer Institute of Canada to Dr. A. Cantero, Director of the Research Laboratories, and by funds from the Fondation Biermans.