This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Robbins, J. Articles by Weathers, B. Search for Related Content PubMed PubMed Citation Articles by Robbins, J. Articles by Weathers, B.

Iodinated Serum Proteins in Functional Thyroid Carcinoma

Clinical Endocrinology Branch, National Institute of Arthritis and Metabolic Diseases, NIH, Bethesda, Maryland

Iodoproteins in the serum of a patient with functioning thyroid carcinoma and in the plasma and tumors of rats bearing transplantable functioning thyroid tumors were investigated by electrophoresis, density gradient ultracentrifugation, immunoprecipitation, and immunoelectrophoresis. Iodinated serum proteins were found in the blood and tumors in all cases studied and, in some, accounted for essentially all of the iodoprotein in the blood. Most of this material was iodinated serum albumin, but iodinated globulins were also detected. In the case of some rat tumors, particularly in Line 1–8, a large proportion of the iodoprotein in both the tumor and the blood was not precipitated by antiserum against serum protein and also differed from thyroglobulin. The nature of this abnormal iodoprotein was not established.