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Chemotherapy Studies in an Animal Tumor Spectrum

I. Biologic Characteristics of the Tumors¹

A spectrum of 8 tumors has been selected chiefly from 35 transplantable animal tumors used previously for chemotherapeutic studies at Sloan-Kettering Institute. Criteria for selection were based on the sensitivity of the tumors to groups of standard antitumor drugs and on the biologic characteristics of the tumors. The new spectrum consists of the mouse tumors adenocarcinoma EO771, sarcoma T241, melanoma B16, Ridgway osteogenic sarcoma, carcinoma C1025, Mecca lymphosarcoma, and Ehrlich ascites tumor, and the rat tumor Walker carcinosarcoma 256. The biologic characteristics of these tumors have been presented.

¹ Supported by contract SA-43-ph-2445 from the Cancer Chemotherapy National Service Center, National Cancer Institute, National Institutes of Health, Public Health Service.

² Division of Experimental Chemotherapy, Sloan-Kettering Institute for Cancer Research, and Sloan-Kettering Division, Graduate School of Medical Sciences, Cornell University Medical College, New York, NY.

³ Present address: Columbia University, College of Pharmacy, New York, NY.