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Hepatic Catalase Changes and Leucine Incorporation in Talc-injected Mice¹

Department of Pathology, Northwestern University Medical School, Chicago, Illinois

The s.c. injection of talc, MgSiO₃, into mice results in a decrease of hepatic catalase activity. A transient, but marked rise in catalase activity was observed on the 4th day following tale injection. This rise in activity was manifest primarily in the mitochondrial fraction. A concomitant increased incorporation of radioactive leucine occurred in the microsomal fraction. The relationship between the increased catalase activity and increased incorporation of leucine is discussed with respect to enzyme biosynthesis.

¹ Supported in part by a grant (CA 03152-8) from the National Cancer Institute, USPHS, and by the American Cancer Society (Illinois Division).

² Dr. Nishmura is a Research Career Development Awardee (GM K3-244-Ca), USPHS (Present address: Department of Pathology, University of California at Los Angeles Medical School, Los Angeles, California).

Received 6/21/65. Revised 9/17/66.