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Electron Microscopy of the Periosteum in Experimental Avian Osteopetrosis¹

Department of Veterinary Science, University of Florida, Gainesville, Florida, and Department of Veterinary Science, Ohio Agricultural Experiment Station, Wooster, Ohio

The periostia of normal and experimentally produced osteopetrotic tibiae were studied by electron microscopy. The pathologic tissue contained viral particles that were predominantly extracellular in location and closely associated with individual osteoblasts. Particles were about 820–950 Å in diameter, and most contained a prominent nucleoid. Some particles seemed to have tails. The cytoplasm of osteoblasts rarely contained virus.

¹ Supported in part by a grant (H-6580) from the National Heart Institute. Florida Agricultural Experiment Stations Journal Series No. 2176. Ohio Agricultural Experiment Station Journal Series No. 50–65.

Received 7/15/65.