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Studies on the Pathogenesis of Plasma Cell Tumors

I. Effect of Cortisol on Development of Plasma Cell Tumors¹

Research Institute for Skeletomuscular Diseases of the Hospital for Joint Diseases, 1919 Madison Avenue, New York, New York

The effect of administration of cortisol on the development of plasma cell tumors in BALB/c mice was studied. Mice of both sexes were injected i.p. with mineral oil. Mice injected with mineral oil alone demonstrated peritoneal lipogranuloma, hypercellular inflammatory ascites, sustained hyperglobulinemia and high incidence of plasma cell tumor development. Cortisoltreated mice failed to show these changes. Cortisol delayed dramatically the onset of plasma cell tumor development and decreased the total incidence of this neoplasm.

¹ This investigation was supported by a grant, DRG 779, from the Damon Runyon Memorial Fund for Cancer Research.

Received 7/15/65.