This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Levi, E. Articles by Fisher, J. Search for Related Content PubMed PubMed Citation Articles by Levi, E. Articles by Fisher, J.

The Activity of Tolerant Antileukemia Sera

I. In Vivo Effects¹

Immunology Laboratory, Medical Research Institute, Cedars-Sinai Medical Center, Los Angeles, California

Neonatal Dutch rabbits were rendered immunologically tolerant to normal AKR/J mouse tissue. The subsequent immunization of these rabbits with the same types of tissues from AKR/J mice which had spontaneously developed a frank lymphatic leukemia produced antisera which were unique in having minimal mouse toxicity combined with strong antileukemia activity. Anti-normal tissue sera and antileukemia sera formed after the immunization of rabbits not pretreated with normal tissue as neonatals, or antisera from rabbits tolerant to normal tissue, immunized with normal tissue, differed markedly in their murine toxicity and antileukemia effects. Antibodies specific to leukemic antigens are implicated by this work.

¹ This work was supported by Grant E-330 from the American Cancer Society.

² Predoctoral Fellow of USPHS, Summer, 1964.

Received 12/16/64. Revised 9/13/65.