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The Activity of Tolerant Antileukemia Sera

II. In Vitro Activity against Normal Tissue¹

Immunology Laboratory, Medical Research Institute, Cedars-Sinai Medical Center, Los Angeles, California

Using the in vitro cytotoxic index against cells obtained from normal AKR/J mice, a method of predicting and paralleling the in vivo mouse toxicity of tolerant antileukemic, nontolerant antileukemic, tolerant anti-normal tissue, and nontolerant anti-normal tissue sera has been developed. This method offers a good but not perfect correlation between in vitro and in vivo observations.

¹ This work was supported by Grant E-330 from the American Cancer Society.

Received 12/23/64. Revised 11/12/65.