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Chemotherapeutic Studies on a New Transplantable Mouse Liver Tumor (Taper Liver Tumor)¹

Division of Experimental Chemotherapy, Sloan-Kettering Institute for Cancer Research, and the Sloan-Kettering Division, Graduate School of Medical Sciences, Cornell University, New York, New York

Utilization of the Taper liver tumor for the detection of antineoplastic compounds was investigated. The sensitivity of this tumor to 10 established cancerostatic agents was evaluated in 2 ways: by use of T/C values, ratio of mean tumor diameter of treated (T) tumors to the mean tumor diameter of control (C) tumors; and the more comprehensive toxicity differential index, the ratio of the mean slope for tumor-bearing mice under drug treatment to the mean slope of comparable animals subjected to restricted feeding.

Both methods showed Cytoxan, 5-fluoro-2-deoxyuridine, and Velban to be the most effective drugs against the Taper liver tumor.

¹ This study was supported by Contract No. SA-43-ph-2445 with the Cancer Chemotherapy National Service Center, National Cancer Institute, and the Division of Research Facilities and Resources (General Research Support Grant 1S01-FR05534), USPHS.

Received 4/ 6/65. Revised 9/17/65.