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The Growth and Metastasis of Amelanotic Melanomas in Heterologous Hosts¹

Department of Pathology, Yale University School of Medicine, New Haven, Connecticut

The transformation of a hamster melanotic melanoma to an amelanotic melanoma is associated with an enhancement in heterologous transplantability and the attainment of the ability to metastasize in the alien host. Heterologous transfer is successfully accomplished with the eye, brain, testicle, muscle, or subcutaneous space utilized as a transplantation site, and metastasis is rapid and widespread.

¹ Research supported by the Jane Coffin Childs Fund for Medical Research (43), the USPHS, (CA-918), and the American Cancer Society, Inc. (P-336).

Received 5/26/65. Revised 9/21/65.