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Growth-promoting Effect of Acid Mucopolysaccharides on Ehrlich Ascites Tumor

Department of Pathology, Nagoya University School of Medicine, Nagoya, Japan

The effect of acid mucopolysaccharides on the growth of hypotetraploid Ehrlich ascites tumor was investigated using chondroitin sulfate and crude hyaluronic acid.

Chondroitin sulfate solution was given s.c. into the right flank of SM mice, followed immediately by Ehrlich tumor. Average tumor weights in chondroitin sulfate-treated groups on Days 3 and 8 after tumor inoculation were 2–3 times as great as in controls. The survival time of chondroitin sulfate-treated mice was shorter than nontreated ones. By means of the same procedure it was also demonstrated that crude hyaluronic acid solution promoted significant growth of the tumor.

The tumor growth-promoting effect was also studied quantitatively with various amounts and concentrations of chondroitin sulfate and was compared with that of other substances with similar physicochemical properties. The same effect was also observed with the chorioallantoic membrane of embryonated chicken eggs and with ascitic tumor in the abdominal cavity of the mice. Chondroitin sulfate and crude hyaluronic acid enhanced tumor growth; the significance of acid mucopolysaccharide activity is discussed. The results appear to indicate that the proliferation of young connective tissue which produces acid mucopolysaccharides is favorable to the growth of cancer cells.

Received 8/ 9/65.

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