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The Role of Ribonuclease in Regression of Lymphosarcoma P1798¹

Research Institute for Skeletomuscular Diseases of The Hospital for Joint Diseases, 1919 Madison Avenue, New York, New York

RNase activity increases in P1798 lymphoid tumors maintained in BALB/c mice that are undergoing in vitro drug-induced regression. Corticosteroids, 5-fluorouracil, vincristine, vinblastine, methotrexate, and triethylenemelamine produce regression of appropriate sublines of P1798 lymphosarcoma as well as an increase in RNase activity. Numerous other agents tested had no effect either on tumor regression or on RNase activity. Separation of the different cell types by glass bead chromatography showed that the increased RNase activity was in the purified tumor lymphocytes.

¹ These studies were supported by Contract PH43-64-46 from the Cancer Chemotherapy National Service Center, National Cancer Institutes, USPHS.

Received 5/13/65. Revised 11/15/65.