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Induction of Experimental Allergic Encephalomyelitis and Tumor Occurrence in Rats Treated with 4-Dimethylaminoazobenzene and 3,4-Benzpyrene¹

Department of Physiology, Medical Faculty, University of Zagreb and Department of Biology, Ruder Bokovi Institute, Zagreb, Yugoslavia

Antagonisms between 2 simultaneously developing processes were studied by inducing experimental allergic encephalomyelitis in rats bearing liver tumors produced by feeding 4-dimethylaminobenzene (4-DAB) or in nontumorous rats which either received the 4-DAB tumorigenic diet or were treated with a tumorigenic dose of 3,4-benzpyrene.

It was shown that tumorous and pretumorous rats were less susceptible to sensitization with the encephalitogenic vaccine. The occurrence of 4-DAB liver tumors was lower if the encephalitogenic vaccine was injected within about 1 month after the end of the azo dye feeding. The results are discussed in view of the assumption that processes similar to the competition of antigens may be the cause of described antagonisms.

¹ This work was supported by the Federal Nuclear Energy Commission of Yugoslavia, the Federal Research Fund of Yugoslavia, and the Research Fund of Croatia.

² Present address: Department of Hematology, Mount Sinai Hospital, 100th St. and 5th Ave., New York 29, N. Y.

Received 5/26/65. Revised 11/29/65.