This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Ultmann, J. E. Articles by Gellhorn, A. Search for Related Content PubMed PubMed Citation Articles by Ultmann, J. E. Articles by Gellhorn, A.

The Clinical Picture of Hodgkin's Disease¹

Department of Medicine, Columbia University College of Physicians and Surgeons, and the Francis Delafield Hospital, New York, New York

The clinical manifestations and laboratory findings in patients with Hodgkin's disease have been reviewed. Variability of the course makes prognostication for any 1 patient difficult. Extent of disease; histologic appearance; age and sex; involvement of specific organs, such as liver or bone; and response to initial therapy all affect prognosis. The cause of death of patients with Hodgkin's disease may be due to tumor involvement or due to complications, in particular, infections and bleeding. During the past 50 years, improvement in survival of patients has been due largely to identification of patients with local or regional disease and their treatment with aggressive radiotherapy. Current modes of chemotherapy combined with improvements in supportive care have had only modest effects on survival rates. The major obstacle to a rational approach to the problem of Hodgkin's disease is the identification of the etiology of this disorder.

¹ This work was supported by USPHS Research Grant No. R10 CA-02332-11 from the National Cancer Institute, The Health Research Council of the City of New York (I-109), and the Anne Winton Memorial Fund. Requests for reprints should be addressed to: John E. Ultmann, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, New York.

² Career Scientist, The Health Research Council of the City of New York.

³ Clinical Fellow, American Cancer Society.