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Current Clinical Trials in the Radiotherapy of Hodgkin's Disease at Institut Gustave Roussy

Institut Gustave Roussy, Villejuif, Seine, France

Two clinical trials now in progress are described: Stage I and Stage II patients were treated with radical radiotherapy and subsequently randomized into 2 groups; 1 group had no further treatment and the other received weekly injections of Vincaleucoblastine. Patients with generalized disease but without visceral involvement were treated first with chemotherapy. In the case of incomplete remission or cessation of chemotherapy as a result of intolerance, a course of radiotherapy was undertaken. The patients were randomized between minimal radiotherapy (3500 rads to territories with residual lesions) or maximal radiotherapy (3500 rads to all regions initially affected as well as intervening regions). These 2 protocols seem practicable and without undersirable side effects.