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Approaches to Improving the Chemotherapy of Hodgkin's Disease

The University of Texas M. D. Anderson Hospital and Tumor Institute (E. F.), Yale University School of Medicine (V. T. D.), Harvard Medical School and Peter Bent Brigham Hospital (J. H. M.), and the National Cancer Institute (P. P. C.)

Approaches to improving the chemotherapy of Hodgkin's disease are presented and discussed: The dose-response (both antitumor effect and toxicity) curve for chemotherapeutic agents is steep. Prior treatment and duration of disease have an adverse effect on response to chemotherapy. Continued treatment during remission (maintenance treatment) will prolong the duration of remission. Combined treatment at full doses with agents with qualitatively different toxicity can be employed safely. In preliminary studies combination chemotherapy produces an "additive" increase in the objective response, particularly the complete response, rate. The implications of these studies and proposed extensions are presented.