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Effect of Surgery, Hormones, and Nutrition on Mammary Cancer Induced by 3-Methylcholanthrene in Female Wistar Rats¹

Surgical removal of the initial mammary cancer in female Wistar rats given intragastric instillations of 3-methylcholanthrene (NSC-21970) did not affect significantly the appearance of additional mammary cancers. Ovariectomy was the most effective therapeutic procedure for the inhibition of mammary cancer. Exogenous testosterone propionate (NSC-9166) and estradiol benzoate (NSC-9566) temporarily inhibited the appearance of additional neoplasms.

¹ Supported in part by grant CA-07771 from the National Cancer Institute and contract SA-43-ph-4344 from the Cancer Chemotherapy National Service Center, National Cancer Institute, National Institutes of Health, Public Health Service.

² Fels Research Institute, Temple University School of Medicine, Philadelphia, Pennsylvania.