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The Influence of Homologs of Riboflavin on the Growth of Walker Rat Carcinoma 256¹

Department of Biochemistry and the Eugene C. Eppley Institute for Cancer Research, University of Nebraska, College of Medicine, Omaha, Nebraska

7,8-Diethyl-10-(1'-D-ribityl)isoalloxazine (diethyl riboflavin), a potent antagonist of riboflavin in the rat, has been found to be nonspecific in the inhibition of the growth of Walker rat Carcinoma 256. 7-Ethyl-8-methyl-10-(1'-D-ribityl)isoalloxazine (7-ethyl-8-methylflavin) and 7-methyl-8-ethyl-10-(1'-D-ribityl)isoalloxazine (7-methyl-8-ethylflavin) have been found to replace riboflavin for the growth of and the efficency of utilization of food by the riboflavin-deficient Sprague-Dawley rat. These 2 flavins do not, however, show the same interchangeability with riboflavin in the growth of Walker rat Carcinoma 256 in this rat. The growth rate of the tumor in the presence of 7-methyl-8-ethylflavin is indistinguishable from that observed in the presence of riboflavin. The growth rate of the tumor in the presence of 7-ethyl-8-methylflavin is 0.5 that observed in the presence of riboflavin.

¹ This study was supported in part by grants from the National Cancer Institute: C-1677, CY-2940 and CA-07379-01. Part of this report was presented before the 8th Midwestern Biochemical Conference, Columbia, Mo., Nov. 5–6, 1965.

Received 11/ 3/65.