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Influence of Thymectomy and Subsequent Thymus Implantation on Leukemia Induction in Adult C57BL Mice by Radiation and Urethan¹

Department of Experimental Biology, Isaac Wolfson Building, The Weizmann Institute of Science, Rehovoth, Israel

A single exposure of adult C57BL/6 mice to 400 r total-body X-irradiation yielded 5% leukemia; thymectomy reduced the incidence to zero, while subsequent implantation of normal thymus reversed the process. Subsequent urethan treatment raised the incidence in nonthymectomized, irradiated mice to 34% and in thymectomized, irradiated, and thymus-implanted mice to 17%. When the thymus implant was given after instead of before the urethan treatment, the leukemia incidence remained low (4%). These results confirm in adults, what had previously been found in newborn mice, that thymus implantation cannot restore urethan leukemogenesis in thymectomized mice, as it does in the case of radiation leukemogenesis.

¹ The work was supported by Research Grant CA-05455, The National Cancer Institute, USPHS.

Received 11/26/65.